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Perinatal Epidermal Growth Factor Receptor Blockade Prevents Peripheral Nerve Disruption in a Mouse Model Reminiscent of Benign World Health Organization Grade I Neurofibroma

Benign peripheral nerve tumors called neurofibromas are a major source of morbidity for patients with neurofibromatosis type 1. Some neurofibroma Schwann cells aberrantly express the epidermal growth factor receptor (EGFR). In a mouse model in which the CNPase promoter drives expression of human EGF...

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Detalhes bibliográficos
Main Authors: Wu, Jianqiang, Crimmins, Jason T., Monk, Kelly R., Williams, Jon P., Fitzgerald, Maureen E., Tedesco, Susan, Ratner, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1606591/
https://ncbi.nlm.nih.gov/pubmed/16651634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.050859
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