Cerebral Microvascular Amyloid β Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid β Precursor Protein

Cerebral vascular amyloid β-protein (Aβ) deposition, also known as cerebral amyloid angiopathy, is a common pathological feature of Alzheimer’s disease. Additionally, several familial forms of cerebral amyloid angiopathy exist including the Dutch (E22Q) and Iowa (D23N) mutations of Aβ. Increasing ev...

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Bibliographic Details
Main Authors: Miao, Jianting, Xu, Feng, Davis, Judianne, Otte-Höller, Irene, Verbeek, Marcel M., Van Nostrand, William E.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603574/
https://ncbi.nlm.nih.gov/pubmed/16049335
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