Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes

Lung Krüppel-like factor (LKLF/KLF2) is an endothelial transcription factor that is crucially involved in murine vasculogenesis and is specifically regulated by flow in vitro. We now show a relation to local flow variations in the adult human vasculature: decreased LKLF expression was noted at the a...

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Detalhes bibliográficos
Main Authors: Dekker, Rob J., van Thienen, Johannes V., Rohlena, Jakub, de Jager, Saskia C., Elderkamp, Yvonne W., Seppen, Jurgen, de Vries, Carlie J.M., Biessen, Erik A.L., van Berkel, Theo J.C., Pannekoek, Hans, Horrevoets, Anton J.G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603569/
https://ncbi.nlm.nih.gov/pubmed/16049344
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