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β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance

Hepatocyte growth factor (HGF) and its c-met receptor consist of a paired signaling system that has been implicated in the regulation of pancreatic β-cell survival, proliferation, and function. To define the role of HGF/c-met signaling in β-cell biology in vivo, we have generated conditional knockou...

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Bibliografiske detaljer
Main Authors: Dai, Chunsun, Huh, Chang-Goo, Thorgeirsson, Snorri S., Liu, Youhua
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1603568/
https://ncbi.nlm.nih.gov/pubmed/16049329
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