Superoxide Dismutase Inactivation in Pathophysiology of Asthmatic Airway Remodeling and Reactivity

Airway hyperresponsiveness and remodeling are defining features of asthma. We hypothesized that impaired superoxide dismutase (SOD) antioxidant defense is a primary event in the pathophysiology of hyperresponsiveness and remodeling that induces apoptosis and shedding of airway epithelial cells. Mech...

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Bibliographic Details
Main Authors: Comhair, Suzy A.A., Xu, Weiling, Ghosh, Sudakshina, Thunnissen, Frederik B.J.M., Almasan, Alexandru, Calhoun, William J., Janocha, Allison J., Zheng, Lemin, Hazen, Stanley L., Erzurum, Serpil C.
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2005
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Original Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602353/
https://ncbi.nlm.nih.gov/pubmed/15743779
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