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Endostatin Overexpression Specifically in the Lens and Skin Leads to Cataract and Ultrastructural Alterations in Basement Membranes

Endostatin, a proteolytic fragment of type XVIII collagen, has been shown to inhibit angiogenesis, tumor growth, and endothelial cell proliferation and migration. We analyzed its functions in vivo by generating transgenic mice in which it was overexpressed in the skin and lens capsule under the kera...

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Bibliografski detalji
Glavni autori: Elamaa, Harri, Sormunen, Raija, Rehn, Marko, Soininen, Raija, Pihlajaniemi, Taina
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602290/
https://ncbi.nlm.nih.gov/pubmed/15632014
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