A Peroxisome Proliferator-Activated Receptor-α Activator Induces Renal CYP2C23 Activity and Protects from Angiotensin II-Induced Renal Injury

Cytochrome P450 (CYP)-dependent arachidonic acid (AA) metabolites are involved in the regulation of renal vascular tone and salt excretion. The epoxygenation product 11,12-epoxyeicosatrienoic acid (EET) is anti-inflammatory and inhibits nuclear factor-κB activation. We tested the hypothesis that the...

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Hauptverfasser: Muller, Dominik N., Theuer, Juergen, Shagdarsuren, Erdenechimeg, Kaergel, Eva, Honeck, Horst, Park, Joon-Keun, Markovic, Marija, Barbosa-Sicard, Eduardo, Dechend, Ralf, Wellner, Maren, Kirsch, Torsten, Fiebeler, Anette, Rothe, Michael, Haller, Hermann, Luft, Friedrich C., Schunck, Wolf-Hagen
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2004
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602252/
https://ncbi.nlm.nih.gov/pubmed/14742258
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