Inhibition of p38 Mitogen-Activated Protein Kinase Augments Progression of Remnant Kidney Model by Activating the ERK Pathway

p38, a mitogen-activated protein kinase, is a major intracellular signaling molecule involved in inflammation. To test the hypothesis that p38 mediates renal disease progression, we administered a novel p38α inhibitor, NPC31169, to rats with remnant kidneys (RKs). RK rats showed increased p38 activa...

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Main Authors: Ohashi, Ryuji, Nakagawa, Takahiko, Watanabe, Susumu, Kanellis, John, Almirez, Ramona G., Schreiner, George F., Johnson, Richard J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2004
Teme:
Regular Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602246/
https://ncbi.nlm.nih.gov/pubmed/14742254
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