Chronic Exposure to the Carcinogenic Compound Benzo[a]Pyrene Induces Larger and Phenotypically Different Atherosclerotic Plaques in ApoE-Knockout Mice

Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon with atherogenic and carcinogenic properties. The role of B[a]P in carcinogenesis is well established, and thought to exert via enzymatic activation into reactive metabolites that are capable of binding to the DNA leading to uncontrolled pr...

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Main Authors: Curfs, Daniëlle M. J., Lutgens, Esther, Gijbels, Marion J. J., Kockx, Mark M., Daemen, Mat J. A. P., van Schooten, Frederik J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2004
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Regular Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602243/
https://ncbi.nlm.nih.gov/pubmed/14695324
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