Cysteine 10 Is a Key Residue in Amyloidogenesis of Human Transthyretin Val30Met

Type I familial amyloidotic polyneuropathy (FAP), a systemic amyloidosis, is characterized by aggregation of variant transthyretin (TTR Val30Met) into stable, insoluble fibrils. This aggregation is caused by genetic and environmental factors. Genetic factors have been studied extensively. However, l...

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Bibliographic Details
Main Authors: Takaoka, Yutaka, Ohta, Mika, Miyakawa, Kazuhisa, Nakamura, Osamu, Suzuki, Misao, Takahashi, Kiyoshi, Yamamura, Ken-ichi, Sakaki, Yoshiyuki
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2004
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Animal Model
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1602210/
https://ncbi.nlm.nih.gov/pubmed/14695346
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