Co-precipitation molecules hemopexin and transferrin may be key molecules for fibrillogenesis in TTR V30M amyloidogenesis

The disease model of familial amyloidotic polyneuropathy—7.2-hMet30 mice—manifests amyloid deposition that consists of a human amyloidogenic mutant transthyretin (TTR) (TTR V30M). Our previous study found amyloid deposits in 14 of 27 7.2-hMet30 mice at 21–24 months of age. In addition, non-fibrillar...

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Detalhes bibliográficos
Publicado no:Transgenic Res
Main Authors: Ohta, Mika, Sugano, Aki, Hatano, Naoya, Sato, Hirotaka, Shimada, Hirofumi, Niwa, Hitoshi, Sakaeda, Toshiyuki, Tei, Hajime, Sakaki, Yoshiyuki, Yamamura, Ken-ichi, Takaoka, Yutaka
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5847157/
https://ncbi.nlm.nih.gov/pubmed/29288430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-017-0054-x
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