Suppression of Mcl-1 via RNA interference sensitizes human hepatocellular carcinoma cells towards apoptosis induction

BACKGROUND: Hepatocelluar carcinoma (HCC) is one of the most common cancers worldwide and a major cause of cancer-related mortality. HCC is highly resistant to currently available chemotherapeutic drugs. Defects in apoptosis signaling contribute to this resistance. Myeloid cell leukemia-1 (Mcl-1) is...

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Autores principales: Schulze-Bergkamen, Henning, Fleischer, Binje, Schuchmann, Marcus, Weber, Achim, Weinmann, Arndt, Krammer, Peter H, Galle, Peter R
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2006
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1601962/
https://ncbi.nlm.nih.gov/pubmed/17014711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-6-232
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