An advanced glycation endproduct cross-link breaker can reverse age-related increases in myocardial stiffness

Decreased elasticity of the cardiovascular system is one of the hallmarks of the normal aging process of mammals. A potential explanation for this decreased elasticity is that glucose can react nonenzymatically with long-lived proteins, such as collagen and lens crystallin, and link them together, p...

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Main Authors: Asif, Mohammad, Egan, John, Vasan, Sara, Jyothirmayi, Garikiparthy N., Masurekar, Malthi R., Lopez, Santos, Williams, Chandra, Torres, Ramon L., Wagle, Dilip, Ulrich, Peter, Cerami, Anthony, Brines, Michael, Regan, Timothy J.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16011/
https://ncbi.nlm.nih.gov/pubmed/10706607
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