A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Nonenzymatic glycosylation and cross-linking of proteins by glucose contributes to an age-associated increase in vascular and myocardial stiffness. Some recently sythesized thiazolium compounds selectively break these protein cross-links, reducing collagen stiffness. We investigated the effects of 3...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Vaitkevicius, Peter V., Lane, Mark, Spurgeon, Harold, Ingram, Donald K., Roth, George S., Egan, John J., Vasan, Sara, Wagle, Dilip R., Ulrich, Peter, Brines, Michael, Wuerth, Jean Paul, Cerami, Anthony, Lakatta, Edward G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2001
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14727/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.98.3.1171
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