A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography

We are developing assays for noninvasive, quantitative imaging of reporter genes with positron emission tomography (PET), for application both in animal models and in human gene therapy. We report here a method to improve the detection of lower levels of PET reporter gene expression by utilizing a m...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gambhir, Sanjiv S., Bauer, Eileen, Black, Margaret E., Liang, Qianwa, Kokoris, Mark S., Barrio, Jorge R., Iyer, Meera, Namavari, Mohammad, Phelps, Michael E., Herschman, Harvey R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16007/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.6.2785
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