Aberrant MHC class II expression in mouse joints leads to arthritis with extraarticular manifestations similar to rheumatoid arthritis

Genetic susceptibility to rheumatoid arthritis (RA) is associated with certain MHC class II molecules. To clarify the role of these determinants in RA, we generated the D1CC transgenic mouse that expressed genes involved in antigen processing and presentation by the MHC class II pathway in joints. T...

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Main Authors: Kanazawa, Satoshi, Ota, Shusuke, Sekine, Chiyoko, Tada, Toyohiro, Otsuka, Takanobu, Okamoto, Takashi, Sønderstrup, Grete, Peterlin, B. Matija
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599985/
https://ncbi.nlm.nih.gov/pubmed/16980409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606450103
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