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An intracellular lamellar–nonlamellar phase transition rationalizes the superior performance of some cationic lipid transfection agents

Two cationic phospholipid derivatives with asymmetric hydrocarbon chains were synthesized: ethyl esters of oleoyldecanoyl-ethylphosphatidylcholine (C18:1/C10-EPC) and stearoyldecanoyl-ethylphosphatidylcholine (C18:0/C10-EPC). The former was 50 times more effective as a DNA transfection agent (human...

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Detalles Bibliográficos
Main Authors: Koynova, Rumiana, Wang, Li, MacDonald, Robert C.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2006
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1599970/
https://ncbi.nlm.nih.gov/pubmed/16983097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603085103
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