Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

Mammalian nonhomologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4, and DNA ligase IV (Lig4). Herein, we show that Ku70 and Ku80 deficiency but not DNA-PKcs deficiency results in dramatically increased death of developing embryonic neurons in...

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Hauptverfasser: Gu, Yansong, Sekiguchi, JoAnn, Gao, Yijie, Dikkes, Pieter, Frank, Karen, Ferguson, David, Hasty, Paul, Chun, Jerold, Alt, Frederick W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2000
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC15987/
https://ncbi.nlm.nih.gov/pubmed/10716994
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