Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice

Mammalian nonhomologous DNA end joining employs Ku70, Ku80, DNA-dependent protein kinase catalytic subunit (DNA-PKcs), XRCC4, and DNA ligase IV (Lig4). Herein, we show that Ku70 and Ku80 deficiency but not DNA-PKcs deficiency results in dramatically increased death of developing embryonic neurons in...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Gu, Yansong, Sekiguchi, JoAnn, Gao, Yijie, Dikkes, Pieter, Frank, Karen, Ferguson, David, Hasty, Paul, Chun, Jerold, Alt, Frederick W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15987/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716994/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.6.2668
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