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Acceleration of Amyloid β-Peptide Aggregation by Physiological Concentrations of Calcium

Alzheimer’s Disease (AD) is characterized by the accumulation of aggregated amyloid β-peptide (Aβ) in the brain. The physiological mechanisms and factors that predispose to Aβ aggregation and deposition are not well understood. In this report, we show that calcium can predispose to Aβ aggregation an...

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Hlavní autoři: Isaacs, Adrian M., Senn, David B., Yuan, Menglan, Shine, James P., Yankner, Bruce A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595535/
https://ncbi.nlm.nih.gov/pubmed/16870617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M602061200
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