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Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora

Homologous integration of a foreign DNA segment into a chromosomal target sequence enables precise disruption or replacement of genes of interest and provides an effective means to analyze gene function. However, integration after transformation is predominantly nonhomologous in most species other t...

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Библиографические подробности
Главные авторы: Ishibashi, Kazuma, Suzuki, Keiichiro, Ando, Yoshinori, Takakura, Chihiro, Inoue, Hirokazu
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2006
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595443/
https://ncbi.nlm.nih.gov/pubmed/17003123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604477103
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