Superoxide Dismutase B Gene (sodB)-Deficient Mutants of Francisella tularensis Demonstrate Hypersensitivity to Oxidative Stress and Attenuated Virulence

A Francisella tularensis live vaccine strain mutant (sodB(Ft)) with reduced Fe-superoxide dismutase gene expression was generated and found to exhibit decreased sodB activity and increased sensitivity to redox cycling compounds compared to wild-type bacteria. The sodB(Ft) mutant also was significant...

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Bibliographic Details
Main Authors: Bakshi, Chandra Shekhar, Malik, Meenakshi, Regan, Kevin, Melendez, J. Andres, Metzger, Dennis W., Pavlov, Vitaly M., Sellati, Timothy J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Molecular Biology of Pathogens
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1595384/
https://ncbi.nlm.nih.gov/pubmed/16923916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00266-06
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