Porphyromonas gingivalis Fimbriae Proactively Modulate β(2) Integrin Adhesive Activity and Promote Binding to and Internalization by Macrophages

In monocytes, the fimbriae of the oral pathogen Porphyromonas gingivalis activate cross talk signaling from Toll-like receptor 2 (TLR2) to the β(2) integrin CD11b/CD18, leading to the induction of the high-affinity state of the latter receptor. CD14 plays an important role in this “inside-out” proad...

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Main Authors: Hajishengallis, George, Wang, Min, Harokopakis, Evlambia, Triantafilou, Martha, Triantafilou, Kathy
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2006
Ábhair:
Molecular Pathogenesis
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1594907/
https://ncbi.nlm.nih.gov/pubmed/16988241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00784-06
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