Mice with a Targeted Mutation of Patched2 Are Viable but Develop Alopecia and Epidermal Hyperplasia

Hedgehog (Hh) signaling plays pivotal roles in tissue patterning and development in Drosophila melanogaster and vertebrates. The Patched1 (Ptc1) gene, encoding the Hh receptor, is mutated in nevoid basal cell carcinoma syndrome, a human genetic disorder associated with developmental abnormalities an...

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Bibliographic Details
Main Authors: Nieuwenhuis, Erica, Motoyama, Jun, Barnfield, Paul C., Yoshikawa, Yoshiaki, Zhang, Xiaoyun, Mo, Rong, Crackower, Michael A., Hui, Chi-chung
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592833/
https://ncbi.nlm.nih.gov/pubmed/16914743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00295-06
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