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Wnt-5a/Ca(2+)-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells

Wnt-5a has been shown to influence the metastatic behavior of human breast cancer cells, and the loss of Wnt-5a expression is associated with metastatic disease. We show here that NFAT1, a transcription factor connected with breast cancer metastasis, is activated by Wnt-5a through a Ca(2+) signaling...

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Auteurs principaux: Dejmek, Janna, Säfholm, Annette, Kamp Nielsen, Christian, Andersson, Tommy, Leandersson, Karin
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592795/
https://ncbi.nlm.nih.gov/pubmed/16880514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02354-05
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