Defining a Link with Autosomal-Dominant Polycystic Kidney Disease in Mice with Congenitally Low Expression of Pkd1

Mouse models for autosomal-dominant polycystic kidney disease (ADPKD), derived from homozygous targeted disruption of Pkd1 gene, generally die in utero or perinatally because of systemic defects. We introduced a loxP site and a loxP-flanked mc1-neo cassette into introns 30 and 34, respectively, of t...

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Main Authors: Jiang, Si-Tse, Chiou, Yuan-Yow, Wang, Ellian, Lin, Hsiu-Kuan, Lin, Yuan-Ta, Chi, Ying-Chih, Wang, Chi-Kuang Leo, Tang, Ming-Jer, Li, Hung
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2006
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592650/
https://ncbi.nlm.nih.gov/pubmed/16400024
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