Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone β receptor inhibits mitotic progression

Overexpression of pituitary tumor–transforming 1 (PTTG1) is associated with thyroid cancer. We found elevated PTTG1 levels in the thyroid tumors of a mouse model of follicular thyroid carcinoma (TRβ(PV/PV) mice). Here we examined the molecular mechanisms underlying elevated PTTG1 levels and the cont...

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Главные авторы: Ying, Hao, Furuya, Fumihiko, Zhao, Li, Araki, Osamu, West, Brian L., Hanover, John A., Willingham, Mark C., Cheng, Sheue-yann
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2006
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1592548/
https://ncbi.nlm.nih.gov/pubmed/17039256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28598
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