Antihyperalgesic effects of infection with a preproenkephalin-encoding herpes virus

To test the utility of gene therapeutic approaches for the treatment of pain, a recombinant herpes simplex virus, type 1, has been engineered to contain the cDNA for an opioid peptide precursor, human preproenkephalin, under control of the human cytomegalovirus promoter. This virus and a similar rec...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Wilson, Steven P., Yeomans, David C., Bender, Mary Ann, Lu, Ying, Goins, William F., Glorioso, Joseph C.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1999
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15921/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077663/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3211
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