Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants

The structural requirements for generation of amyloid from the plasma protein transthyretin (TTR) are not known, although it is assumed that TTR is partly misfolded in amyloid. In a search for structural determinants important for amyloid formation, we generated a TTR mutant with high potential to f...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Goldsteins, Gundars, Persson, Håkan, Andersson, Karin, Olofsson, Anders, Dacklin, Ingrid, Edvinsson, Åsa, Saraiva, Maria João, Lundgren, Erik
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15903/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077645/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.3108
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!