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Exposure of cryptic epitopes on transthyretin only in amyloid and in amyloidogenic mutants

The structural requirements for generation of amyloid from the plasma protein transthyretin (TTR) are not known, although it is assumed that TTR is partly misfolded in amyloid. In a search for structural determinants important for amyloid formation, we generated a TTR mutant with high potential to f...

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Main Authors: Goldsteins, Gundars, Persson, Håkan, Andersson, Karin, Olofsson, Anders, Dacklin, Ingrid, Edvinsson, Åsa, Saraiva, Maria João, Lundgren, Erik
פורמט: Artigo
שפה:Inglês
יצא לאור: The National Academy of Sciences 1999
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC15903/
https://ncbi.nlm.nih.gov/pubmed/10077645
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