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Predicting the effect of missense mutations on protein function: analysis with Bayesian networks

BACKGROUND: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, many of these methods break down if either one of the two types of data are missing. Furthermore, there is a lack of rigo...

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Detalhes bibliográficos
Main Authors: Needham, Chris J, Bradford, James R, Bulpitt, Andrew J, Care, Matthew A, Westhead, David R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586217/
https://ncbi.nlm.nih.gov/pubmed/16956412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-7-405
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