ABCB1 genotypes and haplotypes in patients with dementia and age-matched non-demented control patients

Amyloid β is an in vitro substrate for P-glycoprotein (P-gp), an efflux pump at the blood brain barrier (BBB). The Multi Drug Resistance (ABCB1) gene, encoding for P-gp, is highly polymorphic and this may result in a changed function of P-gp and may possibly interfere with the pathogenesis of Alzhei...

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Detalhes bibliográficos
Main Authors: Frankfort, Suzanne V, Doodeman, Valerie D, Bakker, Remco, Tulner, Linda R, van Campen, Jos PCM, Smits, Paul HM, Beijnen, Jos H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2006
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1586192/
https://ncbi.nlm.nih.gov/pubmed/16999857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-1-13
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