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Targeted Molecular Dynamics Study of C-Loop Closure and Channel Gating in Nicotinic Receptors
The initial coupling between ligand binding and channel gating in the human α7 nicotinic acetylcholine receptor (nAChR) has been investigated with targeted molecular dynamics (TMD) simulation. During the simulation, eight residues at the tip of the C-loop in two alternating subunits were forced to m...
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| Asıl Yazarlar: | , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Public Library of Science
2006
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1584325/ https://ncbi.nlm.nih.gov/pubmed/17009865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.0020134 |
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