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Transcriptional activation by artificial recruitment in mammalian cells

We show that the typical “nonclassical” activator, which comprises a fusion protein bearing a component of the transcriptional machinery fused to a DNA-binding domain, activates transcription in mammalian cells only weakly when tested with an array of promoters. However, as found in analogous “artif...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Nevado, Julián, Gaudreau, Luc, Adam, Maryse, Ptashne, Mark
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1999
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15827/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10077569/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.6.2674
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