4E-Binding Protein Phosphorylation and Eukaryotic Initiation Factor-4E Release Are Required for Airway Smooth Muscle Hypertrophy

The molecular mechanisms of airway smooth muscle hypertrophy, a feature of severe asthma, are poorly understood. We previously established a conditionally immortalized human bronchial smooth muscle cell line with a temperature-sensitive SV40 large T antigen. Temperature shift and loss of large T cau...

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Autores principales: Zhou, Limei, Goldsmith, Adam M., Bentley, J. Kelley, Jia, Yue, Rodriguez, Michael L., Abe, Mark K., Fingar, Diane C., Hershenson, Marc B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1578595/
https://ncbi.nlm.nih.gov/pubmed/15901615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2004-0411OC
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