Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors

Genetically engineered, neuroattenuated herpes simplex viruses (HSVs) expressing various cytokines can improve survival when used in the treatment of experimental brain tumors. These attenuated viruses have both copies of γ(1)34.5 deleted. Recently, we demonstrated increased survival of C57BL/6 mice...

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Main Authors: Parker, Jacqueline N., Gillespie, G. Yancey, Love, Cammy E., Randall, Suzanne, Whitley, Richard J., Markert, James M.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2000
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC15779/
https://ncbi.nlm.nih.gov/pubmed/10681459
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