Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors

Genetically engineered, neuroattenuated herpes simplex viruses (HSVs) expressing various cytokines can improve survival when used in the treatment of experimental brain tumors. These attenuated viruses have both copies of γ(1)34.5 deleted. Recently, we demonstrated increased survival of C57BL/6 mice...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Parker, Jacqueline N., Gillespie, G. Yancey, Love, Cammy E., Randall, Suzanne, Whitley, Richard J., Markert, James M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC15779/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681459/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040557897
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