Effects of (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxation in dogs and mechanism of hypothermic effects in mice

1. The effects of the novel GABA analogue (2R)-(3-amino-2-fluoropropyl)sulphinic acid (AFPSiA) on transient lower oesophageal sphincter relaxations (TLOSRs) were studied in the dog. In addition, the GABA(A)/GABA(B) selectivity was determined in vitro and in vivo, and the pharmacokinetics and the met...

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Autori principali: Lehmann, Anders, Holmberg, Ann Aurell, Bhatt, Ulhas, Bremner-Danielsen, Marianne, Brändén, Lena, Elg, Susanne, Elebring, Thomas, Fitzpatrick, Kevin, Geiss, William B, Guzzo, Peter, Jensen, Jorgen, Jerndal, Gunilla, Mattsson, Jan P, Nilsson, Karolina, Olsson, Britt-Marie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576248/
https://ncbi.nlm.nih.gov/pubmed/15980875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706299
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