Glibenclamide depletes ATP in renal proximal tubular cells by interfering with mitochondrial metabolism

1. Sulfonylurea drugs, like glibenclamide, stimulate insulin secretion by blocking ATP-sensitive potassium channels on pancreatic beta cells. Renal tubular epithelial cells possess a different class of K(ATP) channels with much lower affinities for sulfonylurea drugs, necessitating the use of microm...

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Autori principali: Engbersen, Richard, Masereeuw, Rosalinde, van Gestel, Miriam A, van der Logt, Elise M J, Smits, Paul, Russel, Frans G M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576225/
https://ncbi.nlm.nih.gov/pubmed/15912128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706275
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