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Atorvastatin reverses age-related reduction in rat hepatic PPARα and HNF-4

1. Old rats are resistant to fibrate-induced hypolipidemia owing to a reduction in hepatic peroxisome proliferator-activated receptor α (PPARα). We tested whether the age-related decrease in PPARα is prevented by atorvastatin (ATV), a hypolipidemic statin. 2. We determined the activity and expressio...

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Detalhes bibliográficos
Main Authors: Sanguino, Elena, Roglans, Nuria, Alegret, Marta, Sánchez, Rosa M, Vázquez-Carrera, Manuel, Laguna, Juan C
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576214/
https://ncbi.nlm.nih.gov/pubmed/15912134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706260
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