Direct gas measurements indicate that the novel cyclooxygenase inhibitor AZD3582 is an effective nitric oxide donor in vivo

1. AZD3582 [4-(nitrooxy)butyl-(2S)-2-(6-methoxy-2-naphthyl)propanoate] is a COX-inhibiting nitric oxide donor that inhibits COX-1 and COX-2. It is as effective as naproxen in models of pain and inflammation, but causes less gastroduodenal damage. Nitric oxide (NO) is generated from AZD3582 in vitro,...

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Main Authors: Adding, L Christofer, Agvald, Per, Andersson, Lars I, Jonzon, Bror, Hoogstraate, Janet, Gustafsson, Lars E
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576184/
https://ncbi.nlm.nih.gov/pubmed/15852032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706236
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