Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis

1. We have previously demonstrated that nitric oxide (NO) triggers CD34(+)-derived megakaryocyte apoptosis. We here show that prostacyclin (PGI(2)) inhibits PAPA/NO-induced megakaryocyte death detected by fluorescent microscopy and flow cytometry. 2. The cAMP-specific phosphodiesterase inhibitor, Ro...

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Bibliographic Details
Main Authors: Gabriel Pozner, Roberto, Negrotto, Soledad, D'Atri, Lina Paola, Lidia Kotler, Mónica, Angela Lazzari, María, Martin Gomez, Ricardo, Schattner, Mirta
Format: Artigo
Language:Inglês
Published: 2005
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Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576150/
https://ncbi.nlm.nih.gov/pubmed/15778737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706200
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