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Prostacyclin prevents nitric oxide-induced megakaryocyte apoptosis
1. We have previously demonstrated that nitric oxide (NO) triggers CD34(+)-derived megakaryocyte apoptosis. We here show that prostacyclin (PGI(2)) inhibits PAPA/NO-induced megakaryocyte death detected by fluorescent microscopy and flow cytometry. 2. The cAMP-specific phosphodiesterase inhibitor, Ro...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2005
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1576150/ https://ncbi.nlm.nih.gov/pubmed/15778737 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706200 |
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