Protein trafficking abnormalities: a new mechanism in drug-induced long QT syndrome

Drug induced long QT syndrome (LQTS) can lead to cardiac arrhythmias and sudden death, and has emerged as a worldwide problem. Most drugs that cause this are thought to directly block a specific cardiac ion channel (KCNH2 or hERG) that carries the rapidly activating delayed rectifier potassium curre...

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Bibliographic Details
Main Authors: Eckhardt, Lee L, Rajamani, Sridharan, January, Craig T
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2005
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Commentary
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576114/
https://ncbi.nlm.nih.gov/pubmed/15711590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706143
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