Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine

1. Block of the human two-pore domain potassium (2-PK) channel TREK-1 by fluoxetine (Prozac(R)) and its active metabolite, norfluoxetine, was investigated using whole-cell patch-clamp recording of currents through recombinant channels in tsA 201 cells. 2. Fluoxetine produced a concentration-dependen...

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Autori principali: Kennard, Louise E, Chumbley, Justin R, Ranatunga, Kishani M, Armstrong, Stephanie J, Veale, Emma L, Mathie, Alistair
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576064/
https://ncbi.nlm.nih.gov/pubmed/15685212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706068
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