Anxiogenic properties of an inverse agonist selective for α3 subunit-containing GABA(A) receptors

1. α3IA (6-(4-pyridyl)-5-(4-methoxyphenyl)-3-carbomethoxy-1-methyl-1H-pyridin-2-one) is a pyridone with higher binding and functional affinity and greater inverse agonist efficacy for GABA(A) receptors containing an α3 rather than an α1, α2 or α5 subunit. If doses are selected that minimise the occu...

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Autori principali: Atack, John R, Hutson, Peter H, Collinson, Neil, Marshall, George, Bentley, Graham, Moyes, Christopher, Cook, Susan M, Collins, Ian, Wafford, Keith, McKernan, Ruth M, Dawson, Gerard R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2005
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1576012/
https://ncbi.nlm.nih.gov/pubmed/15655523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706056
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