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TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

1. TRPM2 (melastatin-like transient receptor potential 2 channel) is a nonselective cation channel that is activated under conditions of oxidative stress leading to an increase in intracellular free Ca(2+) concentration ([Ca(2+)](i)) and cell death. We investigated the role of the DNA repair enzyme...

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Détails bibliographiques
Auteurs principaux: Fonfria, Elena, Marshall, Ian C B, Benham, Christopher D, Boyfield, Izzy, Brown, Jason D, Hill, Kerstin, Hughes, Jane P, Skaper, Stephen D, McNulty, Shaun
Format: Artigo
Langue:Inglês
Publié: 2004
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575275/
https://ncbi.nlm.nih.gov/pubmed/15302683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705914
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