Ranolazine: Ion-channel-blocking actions and in vivo electrophysiological effects

1. Ranolazine is a novel anti-ischemic drug that prolongs the QT interval. To evaluate the potential mechanisms and consequences, we studied: (i) Ranolazine's effects on HERG and IsK currents in Xenopus oocytes with two-electrode voltage clamp; (ii) effects of ranolazine, compared to D-sotalol,...

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Hlavní autoři: Schram, Gernot, Zhang, Liming, Derakhchan, Katayoun, Ehrlich, Joachim R, Belardinelli, Luiz, Nattel, Stanley
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575187/
https://ncbi.nlm.nih.gov/pubmed/15277312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705879
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