Levetiracetam inhibits Na(+)-dependent Cl(−)/HCO(3)(−) exchange of adult hippocampal CA3 neurons from guinea-pigs

1. The novel anticonvulsant levetiracetam (LEV) was tested for effects on bioelectric activity and intracellular pH (pHi) regulation of hippocampal CA3 neurons from adult guinea-pigs. 2. In 4-aminopyridine-treated slices, LEV (10–100 μM) reduced the frequency of action potentials and epileptiform bu...

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Hlavní autoři: Leniger, Tobias, Thöne, Jan, Bonnet, Udo, Hufnagel, Andreas, Bingmann, Dieter, Wiemann, Martin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575181/
https://ncbi.nlm.nih.gov/pubmed/15249428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705836
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