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Calcitonin gene-related peptide (CGRP) antagonists: blockers of neuronal transmission in migraine

The neuropeptide calcitonin gene-related peptide (CGRP) is a potent vasodilator that is contained in and released from sensory nerves. CGRP has been implicated in migraine, and the nonpeptide CGRP antagonist BIBN4096BS has been shown to be effective in clinical trials in migraine. To date, it has be...

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Bibliographic Details
Main Author: Brain, Susan D
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575173/
https://ncbi.nlm.nih.gov/pubmed/15237096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705806
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