Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart

1. We examined whether antidiabetic drug miglitol could reduce ischaemia/reperfusion-induced myocardial apoptosis by attenuating production. 2. Japanese white rabbits were subjected to 30-min coronary occlusion followed by 4-h reperfusion with miglitol (10 mg kg(−1), i.v., n=20) or saline (n=20). Th...

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Hlavní autoři: Wang, Ningyuan, Minatoguchi, Shinya, Chen, Xuehai, Uno, Yoshihiro, Arai, Masazumi, Lu, ChuanJiang, Takemura, Genzou, Fujiwara, Takako, Fujiwara, Hisayoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1575111/
https://ncbi.nlm.nih.gov/pubmed/15210576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705863
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